Thursday, April 4, 2013

Potential therapy for human prion disease

Apr. 3, 2013 ? Human diseases caused by misfolded proteins known as prions are some of most rare yet terrifying on the planet -- incurable with disturbing symptoms that include dementia, personality shifts, hallucinations and coordination problems. The most well-known of these is Creutzfeldt-Jakob disease, which can be described as the naturally occurring human equivalent of mad cow disease.

Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time identified a pair of drugs already approved for human use that show anti-prion activity and, for one of them, great promise in treating these universally fatal disorders.

The study, led by TSRI Professor Corinne Lasm?zas and performed in collaboration with TSRI Professor Emeritus Charles Weissmann and Director of Lead Identification Peter Hodder, was published this week online ahead of print by the journal Proceedings of the National Academy of Sciences.

The new study used an innovative high-throughput screening technique to uncover compounds that decrease the amount of the normal form of the prion protein (PrP, which becomes distorted by the disease) at the cell surface. The scientists found two compounds that reduced PrP on cell surfaces by approximately 70 percent in the screening and follow up tests.

The two compounds are already marketed as the drugs tacrolimus and astemizole. Tacrolimus is an immune suppressant widely used in organ transplantation. Tacrolimus could prove problematic as an anti-prion drug, however, because of issues including possible neurotoxicity.

However, astemizole is an antihistamine that has potential for use as an anti-prion drug. While withdrawn voluntarily from the U.S. over-the-counter market in 1999 because of rare cardiac arrhythmias when used in high doses, it has been available in generic form in more than 30 countries and has a well-established safety profile. Astemizole not only crosses the blood-brain barrier, but works effectively at a relatively low concentration.

Lasm?zas noted that astemizole appears to stimulate autophagy, the process by which cells eliminate unwanted components. "Autophagy is involved in several protein misfolding neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases," she said. "So future studies on the mode of action of astemizole may uncover potentially new therapeutic targets for prion diseases and similar disorders."

The study noted that eliminating cell surface PrP expression could also be a potentially new approach to treat Alzheimer's disease, which is characterized by the build-up of amyloid ? plaque in the brain. PrP is a cell surface receptor for A? peptides and helps mediate a number of critical deleterious processes in animal models of the disease.

The first author of the study, "Unique Drug Screening Approach for Prion Diseases Identifies Tacrolimus and Astemizole as Antiprion Agents," is Yervand Eduard Karapetyan of The Scripps Research Institute. Other authors include Gian Franco Sferrazza, Minghai Zhou, Gregory Ottenberg, Timothy Spicer, Peter Chase, Mohammad Fallahi, Peter Hodder and Charles Weissmann of The Scripps Research Institute.

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The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Y. E. Karapetyan, G. F. Sferrazza, M. Zhou, G. Ottenberg, T. Spicer, P. Chase, M. Fallahi, P. Hodder, C. Weissmann, C. I. Lasmezas. Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1303510110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/D8wf0tOnTHw/130403154305.htm

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Facebook unveils 'Home' for Android phones

MENLO PARK, Calif. (AP) ? With its new "Home" on Android gadgets, Facebook aims to put its social network at the center of people's mobile experiences.

If users choose to download Facebook's Home software starting on April 12, the social network will become the hub of their Android smartphones. A phone from HTC that comes pre-loaded with Home will also be available starting that day, with AT&T Inc. as the carrier.

The idea behind the software is to bring Facebook content right to the home screen, rather than requiring users to check apps. "Home" comes amid rapid growth in the number of people who access Facebook from phones and tablet computers. Of its 1.06 billion monthly users, 680 million log in to Facebook using a mobile gadget.

The service is part of Facebook's move to shift its users' focus from "apps and tasks" to people, said CEO Mark Zuckerberg during Home's unveiling at the company's Menlo Park, Calif., headquarters on Thursday.

The new product, which resides on the home screen of Android phones, is a family of apps designed to help people share things with their Facebook friends. Rather than seeing a set of apps for email, maps and other services when they first turn on their phones, users will be greeted with photos and updates from their Facebook feeds. There will be ads too, eventually.

"We think this is the best version of Facebook there is," Zuckerberg said.

Zuckerberg says users can have an experience on Android phones that they can't have on other platforms. That's because Google makes the software available on an open-source basis, allowing others to adapt it to their needs.

Recognizing that text messaging is one of the most important tasks on a mobile phone, Facebook also showed off a feature called "chat heads." This lets users communicate with their friends directly from their phone's home screen ? without opening a separate app.

The move that coincides with rapid growth among the number of users who access the social network from smartphones and tablet computers and Facebook's aim to evolve from its Web-based roots into a "mobile-first" company.

"What Facebook wants is to put itself at the front of the Android user experience for as many Facebook users as possible and make Facebook more elemental to their customers' experience," said Forrester analyst Charles Golvin.

The new Home service won't be available on Apple's iPhone and iPad devices. Apple's iOS and Mac operating systems include features that integrate Facebook's services, but Zuckerberg says doing something like Home would require a closer partnership.

Apple had no immediate comment.

The deeper mobile integration will likely help Facebook to attract more mobile advertisers. Though mobile ads were a big concern for Facebook's investors even before the company's initial public offering last May, some of the worry has subsided as the company muscles its way into the market.

Last year, Facebook began showing ads to its mobile audience by shoehorning corporate-sponsored content into users' news feeds, which also include updates from friends and brands they follow. Facebook now faces the challenge of showing people mobile ads without annoying or alienating them.

The mobile advertising market is growing quickly, thanks in large part to Facebook and Twitter, which also entered the space in 2012. Research firm eMarketer expects U.S. mobile ad spending to grow 77 percent this year to $7.29 billion, from $4.11 billion last year.

EMarketer said Wednesday that it expects Facebook Inc. to reap $965 million in U.S. mobile ad revenue in 2013. That's about 2.5 times the $391 million in 2012, the first year that Facebook started showing mobile ads. Clark Fredricksen, vice president at eMarketer, says "there are some clear reasons why a deeper integration with mobile operating systems and handsets make sense for Facebook. At the end of the day, the more deeply Facebook can engage consumers, no matter what device or operating system or handset," the better.

Facebook's stock rose 82 cents, or 3.1 percent, to close at $27.07 following the announcement. It's still 23 percent below its initial public offering price of $35.

___

Barbara Ortutay reported from New York.

Source: http://news.yahoo.com/facebook-unveils-home-android-phones-183648913--finance.html

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White supremacists sought in prison chief's slaying

Investigators in the case of slain Colorado prison chief Tom Clements have begun a search for two white-supremacist prison gang members identified as persons of interest in the case.

The men, James Lohr and Thomas Guolee, are said to be part of the 211 Crew, a gang whose members also included Evan Ebel, the primary suspect in Mr. Clements?s killing. Mr. Ebel died in a shootout with police two days after the March 19 slaying.

Authorities have not elaborated on a tie between Ebel and Messrs. Lohr and Guolee, except to say they believe the three were in touch before the killing, The Denver Post reports.

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But the warning issued Wednesday evening by the sheriff?s office in El Paso County, where Clements was killed, is the first indication that other members of the white supremacist group may have been involved in the slaying.

"These are a couple of names that have come up during the ongoing investigation of the Clements murder," Lt. Jeff Kramer, the public information officer for the sheriff?s office, told the Post. "Because of the circumstances where you have violent folks who are willing to execute a [Department of Corrections] official, we don't want to underestimate these guys.?

Both Lohr and Guolee are wanted on charges unrelated to Clements?s death, the sheriff?s office said, and both are believed to be armed. Kramer said one or both of the men may be headed to Nevada or Texas.

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The investigators? announcement came the same day as reputed 211 gang ?shot caller? Benjamin Davis was sentenced in a Denver court to an additional 108 years in prison on a racketeering charge. Mr. Davis, who is already serving a 30-year conviction for robbery and assault, founded the white supremacist gang in 1995 at Denver County Jail after he claimed his jaw had been broken by a black inmate, the Post reports.

Meanwhile, news emerged earlier this week that Ebel had been released from prison in January as the result of a clerical error. He was supposed to spend four more years in prison for a 2006 assault on a police officer, but authorities mistakenly entered the charge as one to be served co-currently with his other sentences, rather than consecutively.

The week before the deaths of Clements and pizza deliveryman Nathan Leon ? whom Ebel is also suspected of killing ? Colorado authorities flagged his electronic monitoring bracelet for tampering. But by the time police followed up, Ebel had fled.

Two weeks after Ebel?s fatal shootout with police, Mike McLelland, district attorney for Kaufman County, Texas, and his wife were gunned down in their home. That case also has potential connections to a white-supremacist prison gang.

The group in question in that case is the Aryan Brotherhood of Texas, which the Southern Poverty Law Center has described as ?arguably the most violent white supremacist prison gang out there,? according to a Monitor story.

Early news reports floated possible connections between the killings of Clements and the McLellands, but so far no major evidence has emerged to support that idea.

The 211 gang operates exclusively in Colorado, and some have theorized that the group ordered the hit to settle scores with the prison authorities. One month before Clements?s killing, a ?core group? of the gang?s members were moved to another correctional facility, possibly to dilute their strength in the prison system, the Post reports.

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Source: http://news.yahoo.com/colorado-prison-chief-death-two-white-supremacists-sought-165300321.html

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Wednesday, April 3, 2013

Wall Street rises with health insurers, S&P nears record

By Caroline Valetkevitch

NEW YORK (Reuters) - Stocks rose on Tuesday, led by the health care sector after a government decision on payment rates, while factory orders data confirmed the economy is steadily improving.

The S&P 500 closed at another record high, though it fell short of breaking above its all-time intraday high of 1,576.09. The Dow also ended at another record high.

The government dropped plans to cut payments for private Medicare Advantage insurers and instead said it would allow a 3.3 percent raise.

The news boosted shares of some health insurers, including Humana, which derives about two-thirds of its revenue from Medicare Advantage business. The stock jumped 5.5 percent to $79.11 and was among the biggest percentage gainers on the S&P 500. UnitedHealth Group gained 4.7 percent to $61.74.

"They didn't expect the result that they got. That will help with their bottom line," said Quincy Krosby, market strategist at Prudential Financial in Newark, New Jersey.

Strengthening U.S. data has helped stocks rally since the start of the year. On Tuesday, U.S. data showed February factory orders rose 3 percent, slightly above expectations. That follows a weak reading on manufacturing on Monday that sparked a pullback in stocks.

The S&P 500 is now up 10.1 percent since the start of the year.

For the day, the Dow Jones industrial average was up 89.16 points, or 0.61 percent, at 14,662.01. The Standard & Poor's 500 Index was up 8.08 points, or 0.52 percent, at 1,570.25. The Nasdaq Composite Index was up 15.69 points, or 0.48 percent, at 3,254.86.

The S&P 500 surpassed its 2007 closing high last Thursday, while the Dow first broke above its 2007 record on March 5.

Stocks pared gains late in the session, giving investors another reason to question the strength of the recent rally.

"The recent legs of this rally have lacked a bit of conviction," said Mark Luschini, chief investment strategist at Janney Montgomery Scott in Philadelphia. "What's been leading equity markets has been more defensive sectors."

Healthcare sector stocks are still seen as cheap relative to the overall market. Humana, which has a market cap of about $11.9 billion, has a forward price-to-earnings ratio of 9.4, below the S&P 500 P/E average ratio of about 16.5. UnitedHealth has a P/E ratio of 10.6 and Cigna has a P/E ratio of 9.7.

"We do think that healthcare stocks are a nice combination of dividend yields, growth and low valuations and we are very constructive on the sector," said Jim Russell, senior equity strategist for U.S. Bank Wealth Management in Cincinnati.

Other big gainers in the healthcare sector included shares of Cigna, up 2.9 percent at $64.75.

Most investors expect moves to be limited this week before Friday's U.S. monthly payrolls report.

The March jobs report could give clues on how successful the Federal Reserve has been in lowering unemployment, one of the primary headwinds for the economy.

About 200,000 jobs were created last month, according to a Reuters poll, down from 236,000 in February. The unemployment rate is expected to come in at 7.7 percent, unchanged from the previous period, the poll showed.

In an effort to bring down the unemployment rate, the Fed has maintained an accommodative monetary policy, which has also benefited stocks.

Other gainers included Hertz Global Holdings shares, up 6.8 percent to $23.41, after the company forecast strong earnings and revenue through 2015 due to increasing global demand for car rentals and benefits from its recently completed acquisition of Dollar Thrifty.

Among decliners, Delta Airlines Inc shares were off 8.1 percent at $14.94. Delta's unit revenue for March rose at a slower pace than in the prior two months.

Shares of Nasdaq OMX Group Inc plunged 12.8 percent to $27.91 after agreeing to buy a BGC Partners Inc. trading platform. BGC shares were up 48.6 percent at $5.72.

Shares of Hewlett-Packard fell 5.2 percent to $22.10 after Goldman Sachs downgraded them to "sell."

Volume was roughly 5.9 billion shares traded on the New York Stock Exchange, the Nasdaq and the NYSE MKT, below the 2012 average daily closing volume of about 6.45 billion.

Decliners outpaced advancers on the NYSE by about 15 to 14 and on the Nasdaq by about 13 to 10.

(Additional reporting by Angela Moon; Editing by Kenneth Barry and Nick Zieminski)

Source: http://news.yahoo.com/stock-futures-rise-ps-time-intraday-high-view-111045562--sector.html

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Google and Asustek to release second generation Nexus 7 tablet in July, says Reuters

Reuters Google and Asustek to release nextgen Nexus 7 tablet in July

Google's next generation of Nexus 7 tablets from Asus will be Qualcomm-powered and arrive this July, according to Reuters. If its sources are to be believed, Mountain View is aiming to ship eight million units by the end of the year, showing it has a lot of confidence in the upcoming model. Other leaked info shows it to have more screen resolution, a thinner bezel and an unspecified Qualcomm CPU instead of the current model's NVIDIA Tegra 3, possibly to save power. There's no info on pricing or other specs and Google's not speaking at this point, of course -- but if it proves accurate, hopefully the two companies have learned their lesson from the current model's runaway success and will ramp production accordingly.

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Source: Reuters

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/2m1oFUceebM/

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Apple apologizes in China after service criticism

In this Monday April 1, 2013 photo, a man leaves an Apple store with an iPhone and an iPad in his hands in central Beijing, China. Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism. (AP Photo/Alexander F. Yuan)

In this Monday April 1, 2013 photo, a man leaves an Apple store with an iPhone and an iPad in his hands in central Beijing, China. Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism. (AP Photo/Alexander F. Yuan)

FILE - In this Tuesday, Feb. 28, 2012 file photo, a man walks past an advertisement of Apple's iPad 2 in Shanghai, China. Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism. (AP Photo/Eugene Hoshiko, File)

FILE - In this Friday, July 20, 2012 file photo, an elderly man, left, watches tutorial videos after he bought a new iPad at an Apple Store in Beijing. Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism. (AP Photo/Alexander F. Yuan)

FILE - In this Tuesday, Oct. 23, 2012 file photo, Apple CEO Tim Cook speaks during an event to announce new products, including the iPad mini, in San Jose, Calif.,. Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism. Apple responded with the apology from Cook. ?We've come to understand through this process that because of our poor communication, some have come to feel that Apple's attitude is arrogant and that we don't care about or value feedback from the consumer,? Cook's Chinese statement said, as translated by The Associated Press. ?For the concerns and misunderstandings passed on to the consumer, we express our sincere apologies.? (AP Photo/Marcio Jose Sanchez)

(AP) ? Apple apologized to Chinese consumers after government media attacked its repair policies for two weeks in a campaign that reeked of economic nationalism.

A statement Apple posted in Chinese on its website Monday said the complaints had prompted "deep reflection" and persuaded the company of the need to revamp its repair policies, boost communication with Chinese consumers and strengthen oversight of authorized resellers.

State broadcaster CCTV and the ruling Communist Party's flagship newspaper, People's Daily, had led the charge against the American company. They accused Apple Inc. of arrogance, greed and "throwing its weight around" and portrayed it as just the latest Western company to exploit the Chinese consumer.

The attacks quickly backfired, though, and were mocked by the increasingly sophisticated Chinese consumers who revere Apple and its products. State-run media also inadvertently revived complaints over shoddy service by Chinese companies.

Nonetheless, Apple responded with an apology from CEO Tim Cook.

"We've come to understand through this process that because of our poor communication, some have come to feel that Apple's attitude is arrogant and that we don't care about or value feedback from the consumer," Cook's Chinese statement said, as translated by The Associated Press. "For the concerns and misunderstandings passed on to the consumer, we express our sincere apologies."

Although Apple enjoys strong support from Chinese consumers, the vehemence of the attacks and the importance of the Chinese market appeared to have persuaded the company to appear contrite.

The People's Daily newspaper ran an editorial last Wednesday headlined "Strike down Apple's incomparable arrogance."

"Here we have the Western person's sense of superiority making mischief," the newspaper wrote. "If there's no risk in offending the Chinese consumer, and it also makes for lower overheads, then why not?"

Chinese observers accused People's Daily of gross hypocrisy and pointed out that the newspaper had maintained a stony silence when Chinese companies were implicated over food safety, pollution and other scandals. Meanwhile, CCTV was shamed when it emerged that celebrities had been recruited to blast Apple on Weibo, China's version of Twitter, in what had been billed as a grassroots campaign.

"The public responded in two ways to this incident," popular commentator Shi Shusi wrote on his Weibo account. "One group supports this criticism but quite a number of people felt that there are state monopolies which have severely violated customer's rights, but which are not being exposed."

Popular business magazine Caijing said its readers identified a long list of abusers, including state banks that lend to those with political connections while stiffing ordinary savers with low rates on deposits; a government oil company that sets gas prices and other rates as it sees fit; and state telecom providers notorious for their lack of customer service.

"If media is going to go after Apple, let's hope they spare some thought for those big Chinese communications companies and other monopolies, the ones that enrich special interests in the name of being publicly owned," Cai Tongqi, a lawyer from the eastern province of Jiangsu, wrote on Weibo.

Consumers seem unfazed by the state media's attacks on Apple.

Perusing the wares at an Apple reseller in Beijing's tony China World mall, recent college graduate Zeng Lu said she considered the controversy a sign of the Chinese consumer's growing maturity.

"It's great to see Chinese consumers standing up for their rights, but it's ridiculous for the People's Daily to get involved," Zeng said. "They should be criticizing state companies instead."

Apple's popularity flies in the face of China's ardent attempts to push its own brands and develop internationally competitive companies. The company also has resisted trends to enter joint ventures and move research and development to China. It also ignores big state media such as CCTV and People's Daily. Apple relies on Chinese factories, though, to make iPads, iPhones and other popular products.

Sales of Apple products in the region, which includes Taiwan and Hong Kong, grew 67 percent to $6.8 billion in the first three months of 2013, compared with the same period a year earlier, according to the company. Apple sold 2 million iPhone 5s during the first weekend it was available in China, in December.

The region is Apple's third largest market, accounting for 13 percent of all sales last year. More than 17,000 outlets sell its products in mainland China, a figure that includes 11 Apple stores and 400 premium resellers. In January, Cook said he expects China to replace North America as its largest source of revenue in the foreseeable future.

The attacks on Apple center on complaints over Apple's repair policies in China ? specifically its practice of only replacing faulty parts rather than providing new iPhones, as it does in other markets. Critics say that allows Apple to avoid having to extend its service warranty by another year. Until Monday, the Cupertino, California-based company had kept silent apart from issuing a statement March 23 explaining its repair policy and pledging its deep respect for the Chinese consumer.

Yet consumers and analysts say the complaints hardly justify Beijing's campaign of vilification. Such nationalist outbursts are not uncommon, although previous campaigns against foreign companies have often been tied to perceived national slights, as often befalls Japanese firms in China. Beijing accused Google of being an arm of American "information imperialism" after the company announced in March 2010 that it would cease censoring its search responses inside mainland China and instead send visitors to its uncensored search engine in Hong Kong.

Beijing is also angry over Washington's efforts to exclude Chinese high-tech firms Huawei Technologies Ltd. and ZTE Corp. from the U.S. market, amid worries over security. A spending bill signed by President Barack Obama two weeks ago includes a clause barring NASA, the National Science Foundation and the Justice and Commerce Departments from contracting with firms tied to the Chinese government.

Washington and Beijing have also sparred over more recent hacking attacks, including a forensically detailed report by cybersecurity firm Mandiant that tied Chinese hacking to a unit of the People's Liberation Army based in Shanghai.

Apple, however, may have been singled out simply because it is "the biggest open target," said Jim McGregor, senior counselor at consultancy APCO Worldwide.

"We're still seeing a lot of things wrapped up in economic nationalism," McGregor said.

Even before Monday's apology, he had predicted Apple would make a show of contrition to get its relations with the Chinese authorities back on track.

Duncan Clark, managing director of BDA China Ltd., a Beijing research firm, said the assault probably stems from a combination of factors, including the failure of Chinese companies to make breakthroughs in high-end consumer electronics.

"There's a general sense of frustration that China can't move further up the value chain," Clark said.

___

Online:

Apple statement (in Chinese): http://www.apple.com.cn/support/warranties

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-01-China-Attacking%20Apple/id-b827fb4735d4401e8e9b21242d0af02c

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Cold, Wet Weather for North Texas: Latest Forecast Update

COLD, WET WEATHER NEXT 48 HOURS

Showers and thunderstorms are rumbling thru North Texas this afternoon.? The heaviest rain has been south and east of Dallas.? No severe weather as of 3pm, but a few stronger storms are possible for areas southeast of a line from Sulphur Springs to Kaufman to Corsicana this evening.? The greater severe threat is in the Hill Country and far south Texas.? Below you can see the area shaded in yellow under a Severe Thunderstorm Watch until 11pm.

KTVT Street Level

STRONG UPPER LEVEL STORM BRINGS US MORE RAIN

We aren?t done with the rain yet.? Below you can see a strong upper level low spinning over Colorado.? This will dive south and track right along the Red River tomorrow and tomorrow night.? This will bring more widespread rain to the area.

TX SatRad Master1

COLD AIR FILTERING INTO THE AREA

Cold air is starting to invade the area.? Most areas west of I-35 have been in the colder air all afternoon with temperatures in the 50s.? To the east, temperatures were in the 70s.? But the cold air will win out and everyone will see cold temperatures tonight and tomorrow staying in the 40s and 50s tonight and all day tomorrow.

Here?s a look at temperatures at 3pm today to show you the big spread.

3PM TEMPS

NTX Temp Plot

RAIN CHANCES

Rain coverage will be highest tomorrow and tomorrow night as the upper leve low tracks overhead.? We are not looking at much in the way of severe weather.? In fact, it will be mainly be rain with a few isolated thunderstorms.

Rain Chances Graph

ADDITIONAL RAIN

Most areas are looking at a total of 1? to 2? of rain from today?s rain thru Thursday morning.? Some areas may see a little more and some a little less.? Here is a look at what our forecast models are showing for rainfall totals at DFW.? There is quite a variance.

CompuerModelRainfall

RAIN CHANCES

I have put together several maps showing different time frames to give you a sense where I think the greatest coverage of rain will be thru Thursday.

THIS EVENING

NTX Rain Chances

TONIGHT

NTX Rain Chances1

?

TOMORROW ? Cold and wet, with temperatures staying in the 40s and 50s all day long.?

NTX Rain Chances11
TOMORROW NIGHT

NTX Rain Chances111

THURSDAY ? Most of the rain will exit east during the morning, but it will still be cool with high temperatures in the upper 50s.

NTX Rain Chances11111

7-DAY FORECAST

KTVT 7DAY MASTER

Source: http://dfw.cbslocal.com/2013/04/02/cold-wet-weather-for-north-texas-latest-forecast-update/

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